Inactivation of Penicillins G and K by Liver and Kidney
- 3 January 1947
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 105 (2714) , 18-19
- https://doi.org/10.1126/science.105.2714.18
Abstract
The inactivation of penicillin K is more rapid in the renal-ligated rabbit than in the renal-ligated, eviscerate preparation. Inactivation of penicillin K occurs in the presence of surviving liver and kidney slices. Small amounts of penicillin G were inactivated by liver slices; larger amounts disappeared in the presence of kidney slices. The inactivation of penicillin K in the presence of rabbit liver and kidney slices is demonstrable anaerobically as well as aerobically.Keywords
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