Comparative Studies on in Vitro Methods for Evaluating in Vivo Function of MDR1 P-Glycoprotein
- 1 January 2001
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 18 (12) , 1660-1668
- https://doi.org/10.1023/a:1013358126640
Abstract
Purpose. MDR1 P-glycoprotein (P-gp) plays an important role in determining drug disposition. The purpose of the present study was to establish in vitro models to predict the in vivo function of P-gp. ...Keywords
This publication has 31 references indexed in Scilit:
- In Vitro Substrate Identification Studies for P-glycoprotein-Mediated Transport: Species Difference and Predictability of in Vivo ResultsThe Journal of Pharmacology and Experimental Therapeutics, 2001
- Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug deliveryJournal of Controlled Release, 1999
- P-GLYCOPROTEIN SYSTEM AS A DETERMINANT OF DRUG INTERACTIONS: THE CASE OF DIGOXIN–VERAPAMILPharmacological Research, 1999
- Role of blood‐brain barrier P‐glycoprotein in limiting brain accumulation and sedative side‐effects of asimadoline, a peripherally acting analgaesic drugBritish Journal of Pharmacology, 1999
- BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTERAnnual Review of Pharmacology and Toxicology, 1999
- Pharmacological insights from P-glycoprotein knockout mice.1998
- Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.Journal of Clinical Investigation, 1997
- P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.Journal of Clinical Investigation, 1996
- Competition of Hydrophobic Peptides, Cytotoxic Drugs, and Chemosensitizers on a Common P-glycoprotein Pharmacophore as Revealed by Its ATPase ActivityJournal of Biological Chemistry, 1996
- Characterization of specific cytochrome P450 enzymes responsible for the metabolism of diazepam in hepatic microsomes of adult male ratsBiochemical Pharmacology, 1993