Immunogenic Response to Killed Measles-Virus Vaccine

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Abstract
The cultivation by Enders and Peebles1of measles virus in cell cultures of human and animal tissues has provided simplified procedures for mass propagation of the agent for experimental and vaccine purpose, for quantifying the virus, and for measurement of measles antibody in human and animal sera. Serial passage of the virus in various human cell cultures and in embryonated eggs and adaptation to growth in cell cultures of the chick embryo have made possible the development2of a living attenuated measles-virus vaccine which is both safe and highly efficacious for preventing natural measles in man.3-5 During the early period of investigation of measles in our laboratory and prior to the demonstration of clinical efficacy of live attenuated measles vaccine in man, we undertook to prepare a killed measles-virus vaccine, to assay its antigenicity in animals and in man, and to appraise its efficacy in preventing natural

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