Simple enantiomeric excess determination of amines using chiral selones: unusual N–H⋯Se bonding detected by HMQC1H/77Se NMR spectroscopy
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 10,p. 1125-1126
- https://doi.org/10.1039/cc9960001125
Abstract
One-pot coupling of a chiral selone derivatizing agent to a series of chiral and racemic amines mediated with triphosgene gives adducts in yields ranging from 80–99%; 77Se NMR spectroscopy evaluation of the diastereoisomeric adduct conveniently allows the determination of the enantiomeric excesses of the parent chiral amines.Keywords
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