GAS-CHROMATOGRAPHIC DETERMINATION OF CLOPIDOL IN CHICKEN TISSUES

  • 1 January 1984
    • journal article
    • research article
    • Vol. 67  (5) , 955-957
Abstract
A method was developed for the determination of clopidol residues in chicken tissues. After extraction and cleanup, clopidol was esterified in a 2-phase system to clopidol propionate, which was determined by gas chromatography. The 2-phase system includes, in addition to the clopidol dissolved in methanol, aqueous borax solution, hexane, propionic anhydride and pyridine. Use of these reagents precludes the use of explosive or carcinogenic chemicals in the derivatization step and the method is therefore suitable for routine laboratory analysis. Levels of 0.5 ppb clopidol in tissue can be determined. [Implications with respect to the use of clopidol as a coccidostat in poultry feed are presented.].