Etude des activités NADH et NADPH-ferrédoxine oxydoréductasiques chez Clostridium acetobutylicum

Abstract
The NADH and NADPH-ferredoxin oxidoreductase were studied in C. acetobutylicum. Acetyl-CoA is an obligatory activator of NADH-ferredoxin reductase activity and NADH a competitive inhibitor of ferredoxin-NAD+ reductase activity. These regulations are the same when C. acetobutylicum moves from butylic-type metabolism to butyric-type metabolism; this demonstrates that NADH-ferredoxin oxidoreductase can, through its reversible action, meet the very different cell needs imposed by these 2 types of culture. The physiological function of the clostridial NADPH-ferredoxin oxidoreductase was anabolic as it is with other clostridia.

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