Studies on peptides. LXXXII. Synthesis of [4-Gln]-neurotensin by the methanesulfonic acid deprotecting procedure.
- 1 January 1979
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 27 (9) , 2238-2242
- https://doi.org/10.1248/cpb.27.2238
Abstract
In order to examine the side reaction at the tyrosine residue, i.e., O-sulfonation, that occurs during the methanesulfonic acid deprotection of Arg (p-methoxybenzenesulfonyl), [4-Gln]-neurotensin was synthesized as a model peptide. A mixture of cation scavengers, anisole-thioanisole-o-cresol (1 : 1 : 1), suppressed this side reaction sufficiently for practical peptide synthesis.Keywords
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