Ventilation and Fibrinolytic Activity

1 May 1972

journal article
Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology

Vol. 50 (5) , 389-392
https://doi.org/10.1139/y72-060

Abstract

Previous studies have shown that increases in fibrinolytic activity are related to the intensity of exercise. To provide information as to the mechanism that might initiate this increase in activity the effects of breathing various gas mixtures for 10-min periods were investigated in 11 subjects. Hypercapnia ([Formula: see text], [Formula: see text], [Formula: see text]) and hypocapnia ([Formula: see text], [Formula: see text], [Formula: see text]) were associated with increases in fibrinolytic activity (P < 0.001) whereas no consistent change occurred with hypoxia ([Formula: see text], [Formula: see text], [Formula: see text]), hyperoxia ([Formula: see text],[Formula: see text], [Formula: see text]) and eucapnic hyperventilation ([Formula: see text],[Formula: see text],[Formula: see text]). The average times for lysis to occur with hypocapnia and hypercapnia as compared with the control values were 78 and 84%, respectively.

Keywords

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