REMISSION IN DISSEMINATED COCCIDIOIDOMYCOSIS PRODUCED BY AMPHOTERICIN B

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Abstract
Amphotericin B (Fungizone, E. R. Squibb and Sons, Division of Olin Mathieson Chemical Corp.) produced a remission in a case of disseminated coccidioidomycosis. A total dosage of 3.0 g was administered intravenously in divided doses for 28 weeks. The temperature, white blood count, sedimentation rate, and sputum cultures became normal. Coccidioidal complement fixation titer fell from 1:256 to 1:64 and chest roentgenograms cleared. The patient returned to full duty as an airman in the U. S. Air Force with no evidence of exacerbation for 9 months after all therapy was withdrawn. No undue renal, hepatic, or bone marrow toxicity was observed. Experience in the present case and in a review of the literature to date suggest that at least 1 mg per kg of Amphotericin B must be administered for a prolonged period of time to achieve a remission in disseminated coccidioidomycosis.