MULTIPLE-MYELOMA - SIGNIFICANCE OF PLASMABLASTIC SUBTYPE IN MORPHOLOGICAL CLASSIFICATION

  • 1 January 1985
    • journal article
    • research article
    • Vol. 65  (2) , 305-310
Abstract
Cases (100) of myeloma before chemotherapy were classified as mature (28), intermediate (38), immature (19) or plasmablastic (15). The plasmablastic group had an estimated median survival (Kaplan-Meier method) of 10 mo. compared to 35 mo. for the other types (P < 0.05). Decreased survival in the plasmablastic group was due to more frequent deaths in the 1st 6 mo. There were no significant differences in survival among the mature, intermediate, and immature groups or among patients wtih different morphological grade or asynchrony scores. The plasmablastic myeloma group had more frequent renal insufficiency and higher plasma cell labeling indices, which may have contributed to the shorter survival.

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