Stochastic sensors inspired by biology
Top Cited Papers
- 13 September 2001
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 413 (6852) , 226-230
- https://doi.org/10.1038/35093038
Abstract
Sensory systems use a variety of membrane-bound receptors, including responsive ion channels, to discriminate between a multitude of stimuli. Here we describe how engineered membrane pores can be used to make rapid and sensitive biosensors with potential applications that range from the detection of biological warfare agents to pharmaceutical screening. Notably, use of the engineered pores in stochastic sensing, a single-molecule detection technology, reveals the identity of an analyte as well as its concentration.Keywords
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