Asymmetric Induction in Radical Cyclization Leading to β-Lactams: Formal Synthesis of (+)-PS-5
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (06) , 445-446
- https://doi.org/10.1055/s-1994-22884
Abstract
Tributyltin hydride-mediated radical cyclization of N-[2,2-bis(phenylthio)ethenyl]-α-bromoalkanamides bearing (S)-1-phenylethyl group on the nitrogen atom gave (4S)-4-bis(phenylthio)-methyl-2-azetidinones as major products. The method was applied to the synthesis of a chiral precursor of carbapenem antibiotic (+)-PS-5.Keywords
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