Pharmacokinetics of Desmopressin Administrated as an Oral Lyophilisate Dosage Form in Children With Primary Nocturnal Enuresis and Healthy Adults

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Abstract
The population pharmacokinetics of desmopressin in children with nocturnal enuresis and in healthy adults were compared using a 1‐compartment model with first‐order absorption and first‐order elimination. In addition, the model consisted of a number of transit compartments before absorption to describe a lag‐time. The model gave an adequate description of adult as well as children data and provided a statistically significant better fit to data than a standard lag‐time model. The main difference in the pharmacokinetics between children and adults was the absorption delay. The pharmacokinetic difference was minor and presumably of no clinical relevance.