Iodine-containing organic carbonates as investigative radiopaque compounds

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Abstract
Carbonates containing an iodinated aromatic ring on 1 side of the carbonate linkage and an alkyl group on the other were prepared. The aromatic side consisted of p-iodophenyl, p-iodobenzyl, m-iodobenzyl, 3,5-diiodobenzyl, m-amino-2,4,6-triiodobenzyl, m-acetamido-2,4,6-triiodobenzyl, p-iodophenethyl, p-iodo-sec-phenethyl, 3-(p-iodophenyl)prophyl, 3-(p-iodophenyl)butyl, 2(p-iodobenzyl)butyl and 2-(p-iodobenzyl)hexyl groups. The alkyl portion of the carbonates was derived from alkyl alcohols containing from 2-10 C atoms. The approximate lethal dose of i.p. injections ranged from less than 1 ml/kg to more than 15 ml/kg. An investigation into the use of these compounds as radiopaques for myelography, lymphography, bronchography and salpingography is underway.

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