GABA in Epilepsy: The Pharmacologic Basis
- 1 September 1989
- Vol. 30 (s3) , S1-S11
- https://doi.org/10.1111/j.1528-1157.1989.tb05825.x
Abstract
Summary: GABA transmission plays a key role in controlling seizure activity. The precise nature of its effect depends on the particular location in the brain and the pathway involved. Animal studies have helped to define specific brain regions such as the substantia nigra and area tempestas that are critical in controlling seizure activity. Antiepileptic drugs such as vigabatrin [gamma vinyl GABA (GVG)], a drug rationally developed to treat resistant epilepsy, can enhance GABA transmission in these regions and may thereby afford seizure protection.Keywords
This publication has 19 references indexed in Scilit:
- Anticonvulsant action of GABA receptor blockade in the nigrotectal target regionBrain Research, 1989
- Substantia nigra-mediated anticonvulsant actions: Role of nigral output pathwaysExperimental Neurology, 1987
- Modification of electroshock and pentylenetetrazol seizure patterns in rats affer precollicular transectionsExperimental Neurology, 1986
- Intranigral muscimol suppresses ethanol withdrawal seizuresBrain Research, 1984
- Lesions of substantia nigra protect against experimentally induced seizuresBrain Research, 1983
- Abortive amygdaloid kindled seizures following micro-injection of γ-vinyl-GABA in the vicinity of substantia nigra in ratsNeuroscience Letters, 1983
- Substantia Nigra: Site of Anticonvulsant Activity Mediated by γ-Aminobutyric AcidScience, 1982
- Intracerebral injection of gamma vinyl GABA: Method for measuring rates of GABA synthesis in specific brain regionsLife Sciences, 1981
- GABAergic denervation of rat substantia nigra: functional and pharmacological propertiesBrain Research, 1980
- Dissociation between drug-induced increases in nerve terminal and non-nerve terminal pools of GABA in vivoEuropean Journal of Pharmacology, 1979