The effect of intensive intermittent maintenance therapy in advanced low-grade non-Hodgkin's lymphoma
- 15 July 1987
- Vol. 60 (2) , 156-160
- https://doi.org/10.1002/1097-0142(19870715)60:2<156::aid-cncr2820600205>3.0.co;2-k
Abstract
One hundred and eleven patients with low-grade histology non-Hodgkin's lymphoma achieving a restaged complete response to one of three induction therapies on Eastern Cooperative Oncology Group (ECOG) protocol EST 2474 were randomized to receive either maintenance treatment with BCNU, cyclophosphamide, vincristine, and prednisone (BCVP) given every 6 weeks for an additional 18 months or no further therapy. Overall toxicity was moderate. The median progression-free survival (PFS) on maintenance therapy was 3.2 years versus 2.0 years for those observed without treatment (P = 0.02). Progression-free survival was significantly shorter for patients with nodular and diffuse pattern (ND), histiocytic or mixed histology compared with pure nodular lymphocytic, or poorly differentiated counterpart (P = 0.0007), thus confirming the prognostic significance of histologic subtypes. However, the overall survival of patients was not improved by maintenance treatment, suggesting that therapy upon relapse was an equally effective alternative clinical strategy.This publication has 18 references indexed in Scilit:
- Karnofsky memorial lecture. The low-grade non-Hodgkin's lymphomas: challenges and opportunities.Journal of Clinical Oncology, 1985
- High-dose pulse chlorambucil. Effective therapy for rapid remission induction in nodular lymphocytic poorly differentiated lymphomaCancer, 1982
- National cancer institute sponsored study of classifications of non-hodgkin's lymphomas. Summary and description of a working formulation for clinical usageCancer, 1982
- Moderate versus intensive chemotherapy of prognostically favorable non-Hodgkin's lymphoma a progress reportCancer, 1980
- CVP—Remission—maintenance in stage I or II non-Hodgkin's lymphomasPreliminary results of a randomized studyCancer, 1979
- No Initial Therapy for Stage III and IV Non-Hodgkin's Lymphomas of Favorable Histologic TypesAnnals of Internal Medicine, 1979
- Combination versus successive single agent chemotherapy in lymphocytic lymphomaCancer, 1978
- Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examplesBritish Journal of Cancer, 1977
- Combined cyclophosphamide, vincristine, and prednisone therapy of malignant lymphomaCancer, 1971
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958