Estimation of sensitivity and specificity of site‐specific diagnostic tests
- 1 July 1990
- journal article
- research article
- Published by Wiley in Journal of Periodontal Research
- Vol. 25 (4) , 193-196
- https://doi.org/10.1111/j.1600-0765.1990.tb00903.x
Abstract
Clinical trials designed to estimate the sensitivity and specificity of periodontal diagnostic tests often use multiple sites per patient as experimental units of analyses. Since site-specific test results within a patient are dependent observations, a correlated binomial model should be employed to estimate the sensitivity and specificity of these diagnostic tests. Ignoring the within-patient correlation can result in an over- or underestimation of the true standard errors.Keywords
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