Antineoplastic properties of arylsulfonylhydrazones of 3-formylpyridazine 2-oxide and 4-formylpyrimidine 3-oxide
- 1 December 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (12) , 1333-1335
- https://doi.org/10.1021/jm00210a036
Abstract
The antineoplastic activity of several arylsulfonylhydrazones of 4-formylpyrimidine 3-oxide and of 3-formylpyridazine 2-oxide was investigated. Derivatives of the latter heteroaromatic N-oxide showed excellent antineoplastic potency against the murine neoplasm Sarcoma 180 but were inactive against leukemia L1210; derivatives of 4-formylpyrimidine 3-oxide were inactive against both of these transplanted tumors.This publication has 0 references indexed in Scilit: