Further Investigations of the γ-Chain in a Ghanaian Adult, Homozygous for Hereditary Persistence of Fetal Haemoglobin
- 1 January 1975
- journal article
- Published by S. Karger AG in Acta Haematologica
- Vol. 53 (5) , 315-320
- https://doi.org/10.1159/000208198
Abstract
The γ chain in a Ghanaian homozygous for hereditary persistence of fetal haemoglobin was considered to be of the Gγtype on the basis of the amino acid analysis of γTp XIV (γ133–144) of the Hb F of this subject [1]. Recently, the sequence of residues γ134–137 of the γ-chain of this subject was determined and found to contain some alanine at position γ136. It is therefore of the Gγ + Aγtype. A rapid technique for the isolation of γCB-3 (γl34–146) peptides in human fetal haemoglobin for Gγ;Aγratio determination is described.Keywords
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