Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats.
- 1 December 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (23) , 7518-7521
- https://doi.org/10.1073/pnas.79.23.7518
Abstract
Antibodies were raised in rats against the poliovirus type 1 capsid proteins, VP1, VP2 and VP3. Antibodies directed against VPI from type 1 poliovirus (Mahoney) neutralized type 1 but not type 2 poliovirus. Antibodies raised against VP2 and VP3 failed to neutralize type 1 virus. Thus, VP1 appears to be a neutralizing antigen for poliovirus and in its denatured form presents to the immune system its neutralizing determinants.Keywords
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