Two Local Hemorrhagic Skin Responses to Bacterial Endotoxin in an Inbred Mouse Strain

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Abstract
The observations previously made by Kelly et al. on production of hemorrhagic skin lesions by dermal injection of bacterial endotoxin in Rockefeller mice have been repeated with the genetically related, highly inbred, BSVS strain. BSVS mice displayed all of the reactions reported by the above authors, but with a significantly increased frequency, and at much lower doses of endotoxins. Pretreatment with Terramycin caused a marked decrease in frequency of reactors to a single injection of endotoxin. This effect gradually diminished over a period of 8 months of continued treatment. It is suggested that the single-injection reaction is a special form of the dermal Shwartzman reaction in which some microbial agent(s) plays an as yet unknown part.

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