Sulfhydryl Variation in Bacterial Enzymes in Relationship to Chemotherapy with the Nitro-Furans.

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Abstract
In the presence of urea, Micrococcus pyogenes var. aureus produces a urease that is inhibited by furacin, p-chloromercuribenzoate and trivalent arsenicals. When the organisms are grown in the absence of urea or when furacin-resistant organisms are grown in media containing urea, ureases are obtained that are not affected by the above inhibitors. Some aspects of resistance to the nitrofurans can be explained by a shift of certain enzymes from the SH to a non-SH form.