Inhibition of the immune response by rapamycin, a new antifungal antibiotic
- 1 February 1977
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 55 (1) , 48-51
- https://doi.org/10.1139/y77-007
Abstract
Rapamycin, a new antifungal antibiotic, inhibited the immune response in rats. It totally prevented the development of 2 experimental immunopathies [experimental allergic encephalomyelitis (EAE) and adjuvant arthritis (AA)] and the formation of humoral (Ig[immunoglobulin)E-like) antibody. It was about half as potent as cyclophosphamide in inhibiting EAE. In AA and on antibody formation, rapamycin and cyclophosphamide were about equipotent, whereas methotrexate was more potent. The immunosuppressant activity of rapamycin appears to be related to inhibition of the lymphatic system.This publication has 1 reference indexed in Scilit:
- Anti-inflammatory and analgesic properties of etodolic acid in ratsCanadian Journal of Physiology and Pharmacology, 1976