Hypopituitarism Associated with Epilepsy Following Head Injury

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Abstract
Two cases of hypopituitarism and epilepsy were described. The first, a [male] of 46, was shot through the head at the age of 15. The bullet entered the left orbit, traversed the pituitary fossa and lodged behind the posterior clinoids. Growth and development ceased and gradually epileptiform seizures supervened. The 2d, a [male] of 48, was injured in World War I by the explosion of a shell. He received several shrapnel wounds and was knocked unconscious. He, also, developed epileptic seizures. They both presented characteristic clinical and laboratory evidence of hypopituitarism. They differed only with respect to stature. The 1st patient was a partial dwarf; the 2d, having received his injury at the age of 22, was of normal size. Both patients responded clinically and biochemically to the adm. of chorionic gonadotrophin, but the convulsions remained unaltered. The 2d patient died after a siege of rheumatic infection which resulted in cardiac and adreno-cortical failure.