Genetic mapping with a thiamine-requiring auxotroph of Escherichia coli K-12 defective in thiamine phosphate pyrophosphorylase

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Abstract
The pathway of thiamine biosynthesis from its pyrimidine and thiozol moieties involves 4 enzymes. Results indicate the structural gene for this enzyme is linked to the thi gene, which is assumed to be the locus responsible for synthesis of the thiazole moiety of thiamine.