A COMPARISON OF THE EFFECTS OF CYCLOSPORIN A AND STANDARD AGENTS ON PRIMARY WOUND-HEALING IN THE RAT

  • 1 January 1985
    • journal article
    • research article
    • Vol. 160  (2) , 135-138
Abstract
Sprague-Dawley rats (86) were randomly allocated to 3 treatment groups given tap water (control group), cyclosporin A (CSA group) and azathioprine and prednisone (AP group). Two incisions, 1 skin and 1 musculofascial, were made in each rat with a standardized technique. The healed incisions were subjected to tensiometery at days 8 and 15 after operation. Histologic examination was undertaken on some wounds. Cyclosporin A in clinical doses does not inhibit skin or musculofascial healing in the rat. Azathioprine and prednisone immunosuppression significantly retarded skin healing on day 8 postoperatively although this had returned to control levels on day 15. Azathioprine and prednisone did not affect musculofascial healing at the administered dose. In the sections available for study, there were no qualitative histologic differences between groups at both days 8 and 15 postoperatively.

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