Involvement of genes uvrD and recB in separate mutagenic deoxyribonucleic acid repair pathways in Escherichia coli K-12 uvrB5 and B/r uvrA155
- 30 June 1980
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 143 (1) , 212-220
- https://doi.org/10.1128/jb.143.1.212-220.1980
Abstract
The UV radiation-induced reversion of nonsense (lacZ53) and missense (leuB19) mutations in uvrB5, uvrB5 uvrD3, uvrB5 recB21 and uvrB5 uvrD3 recB21 strains of E. coli K-12. Nonsense (trpE65) reversion was also compared in similar derivatives of E. coli B/r uvrA155. The uvrD mutation reduced mutagenesis in every case, but had its main effect in cells UV irradiated with low fluences (< 0.6 J m-2). The effect of the recB mutation varied; it decreased Leu and Trp reversion, but had little effect on Lac reversion. The effect of the uvrD recB combination was a gross reduction in mutagenesis. Only in the case of Lac reversion was appreciable mutagenesis detected (at fluences > 0.3 J m-2). Separate uvrD- and recB-controlled pathways exist for UV radiation mutagenesis.This publication has 37 references indexed in Scilit:
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