Modulation of the Immune Response by Plasma Protease Inhibitors.
- 1 January 1982
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 15 (1) , 115-118
- https://doi.org/10.1111/j.1365-3083.1982.tb00629.x
Abstract
In two different cytolytic assays, dose-dependent inhibition of antibody-dependent cellmediated cytotoxicity and natural killing by alpha2-macroglobulin (α2m) and its subunits was observed. α2m subunits were approximately four times more inhibitory in both assays than the native 2m molecule on a molar basis. Analysis of trypsin protein esterase activity demonstrated that α2m subunits were four times more active than the parent molecule.Keywords
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