Studies in detoxication

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Abstract
When phenol-p-sulphonamide is fed to rabbits, a small portion is oxidised to catechol-4-sulphonamide, isolated from acid-hydrolysed urines and characterized by the crystalline methylated derivative, vera-trole-4-sulphondimethylamide. About 1% of the phenol-sulphonamide fed was accounted for as pure veratrole-sulphondimethylamide: probably 4-5% is actually oxidised. Catechol-4-sulphonanilide and other derivatives are described, also the synthesis of catecholsulphonamide from catechol.

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