Abstract
Throughout most of its history, the practice of medicine has been conducted without concern for the levels of drugs in body fluids and tissues. In part this state of affairs was occasioned by methodologic deficiencies, but even after the advent of sophisticated assay technics there was little interest in drug measurements, with the exception of certain chemotherapeutic agents and the management (or at least the forensic work-up) of poisoned patients.The flowering of clinical pharmacology and pharmacokinetics has changed all that. Measurements of biologic fluid concentrations for a number of drugs are now routinely available in many hospitals, and special . . .

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