LIVER-REGENERATION AND LYMPHOCYTE-ACTIVATION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 143  (6) , 914-918
Abstract
A 70% partial hepatectomy in the rat resulted in a massive DNA synthesis not only in the remaining liver cells but also in the lymphoid organs. Serum factor present in the rat after hepatectomy stimulated hepatocytes and lymphocytes in culture. Lethally irradiated rats, followed by a partial hepatectomy, could be restored their regeneration ability only when the lymphocytes taken from rats after hepatectomy were injected. The replications of the regenerating liver cells and the antigen stimulated lymphocytes were seemingly triggered by a common pathway, probably through 3'':5''-cyclic AMP activation.

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