The effect of subthalamic nucleus stimulation on kinaesthesia in Parkinson's disease

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Abstract
Background: Parkinson’s disease is accompanied by deficits in passive motion and limb position sense. Objective: To investigate whether deep brain stimulation of the subthalamic nucleus (STN-DBS) reverses these proprioceptive deficits. Methods and results: A passive movement task was applied to nine patients with Parkinson’s disease and bilateral chronic STN-DBS and to seven controls. Thresholds for 75% correct responses were 0.9° for controls, 2.5° for Parkinson’s disease patients when stimulation was OFF, and 2.0° when stimulation was ON. Conclusions: STN-DBS improves kinaesthesic deficits in Parkinson’s disease, but does not lead to a full recovery of proprioceptive function.

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