Alendronate Is a Specific, Nanomolar Inhibitor of Farnesyl Diphosphate Synthase
- 1 January 2000
- journal article
- Published by Elsevier in Archives of Biochemistry and Biophysics
- Vol. 373 (1) , 231-241
- https://doi.org/10.1006/abbi.1999.1502
Abstract
No abstract availableKeywords
This publication has 30 references indexed in Scilit:
- Nitrogen-Containing Bisphosphonates Inhibit Isopentenyl Pyrophosphate Isomerase/Farnesyl Pyrophosphate Synthase Activity with Relative Potencies Corresponding to Their Antiresorptive Potenciesin Vitroandin VivoBiochemical and Biophysical Research Communications, 1999
- Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitroProceedings of the National Academy of Sciences, 1999
- New Target Enzyme(s) for Bisphosphonates: Inhibition of Geranylgeranyl Diphosphate SynthasePesticide Biochemistry and Physiology, 1998
- Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including RasJournal of Bone and Mineral Research, 1998
- Bisphosphonates: mechanisms of action.Journal of Clinical Investigation, 1996
- Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivoJournal of Bone and Mineral Research, 1995
- Isolation and Characterization of Highly Enriched, Prefusion Mouse Osteoclastic CellsExperimental Cell Research, 1995
- Purification and characterization of recombinant human farnesyl diphosphate synthase expressed in Escherichia coliBiochemical Journal, 1991
- [11] Isopentenyldiphosphate Δ-isomerasePublished by Elsevier ,1985
- [16] Eukaryotic prenyltransferasesPublished by Elsevier ,1985