Synthesis and antiarrhythmic activity of .alpha.,.alpha.-bis[(dialkylamino)alkyl]phenylacetamides

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Abstract
The synthesis and biological evaluation of a series of .alpha.,.alpha.-bis[(dialkylamino)alkyl]phenylacetamides are presented. The compounds are structurally related to the antiarrhythmic agent disopyramide and in many cases had greater antiarrhythmic activity in coronary ligated dogs. Within this series of compounds, a separation of the antiarrhythmic properties from the unwanted cardiac depressant side effects observed with the parent compound was often attained. A discussion of the structure-activity relationships within this series is presented; this work has culminated in the identification of disobutamide as a candidate for clinical evaluation as an antiarrhythmic agent in man.