Serum Progesterone and 17-Hydroxyprogesterone in the Diagnosis of Ectopic Pregnancies and the Value of Progesterone Replacement in Intrauterine Pregnancies when Serum Progesterone Levels Are Low
- 1 January 1992
- journal article
- clinical trial
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 34 (3) , 133-138
- https://doi.org/10.1159/000292745
Abstract
The corpus luteum function was evaluated in patients with surgically confirmed ectopic pregnancy (EP) in a multicenter study. In addition, the minimal threshold of serum progesterone (P) concentration required for salvaging intrauterine pregnancies (IUP) was also examined. Results show that single P or 17-OHP measurements are not diagnostic for EP, since mean P levels in EP were similar to those with spontaneous abortion though significantly lower than those in controls. 17-OHP levels in EP overlapped in 50% with IUP, and the mean levels were significantly lower only at 6-7 weeks. The 17-OHP levels when compared to hCG supports the view that corpus luteum defect is primary. In IUP, P levels < 8 ng/ml still were associated with viable (60%) pregnancy; thus no minimal threshold could be established.Keywords
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