Sexual Dimorphism in the Secondary Immune Response of the Syrian Hamster

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Abstract
The secondary immune response patterns of young adult male and female hamsters injected with SRBC were studied and compared. Females were shown to produce higher number of PFC per spleen than did males. No major differences were shown to exist between males and females using serum hemagglutinin and hemolysin titers as parameters of comparison. The spleens of all animals were evaluated in terms of organ weight, total splenocyte count per spleen and spleen weight expressed as percent of total body weight. A partial but indirect explanation of female advantage over the male is reflected in a significantly greater splenic mass, i.e., lymphoid tissue, for females than for males of equivalent age and weight.

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