Survival after Transfusion of Rh-positive Erythrocytes Previously Incubated with Rh Antibody

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Abstract
Rh-positive erythrocytes were incubated in vitro with serum containing Rh antibody of the albumin-agglutinin type and then transfused to anemic patients. The erythrocytes retained their coat of antibody, as demonstrated by the direct Coombs test, for long periods after transfusion. When these Rh-positive erythrocytes, sensitized in vitro, are transfused to an Rh-positive recipient, the Rh antibody becomes distributed among the erythrocytes of both donor and recipient. The bulk of sensitized erythrocytes survive normally after transfusion.