Genetic mapping using haplotype and model‐free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31‐33

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Abstract
We report further evidence for our previous suggestion [Garner et al., 2001 : Am J Hum Genet 68:1061–1064] of a locus on 5q predisposing to bipolar I disorder (BP-I) in an extended Costa Rican pedigree. We genotyped additional microsatellite markers in this region and applied a multi-point non-parametric linkage analysis (SimWalk2). Significant identity-by-descent allele sharing among affected relatives was observed for all of the 20 markers tested in a segment of approximately 15 cM. Most affected individuals shared a single haplotype over this region; breaks within this haplotype may suggest a more restricted candidate location for a BP-I gene. These results support the suggestion that a locus at 5q31-33, together with a previously reported locus at 18q22-23, may provide the major genetic risk for BP-I in this family.
Funding Information
  • The National Institutes of Health, (NIH) (to L.A.M.) (MH-01748)
  • The National Institutes of Health, (NIH) (to N.B.F.) (MH-00916, MH-49499)
  • FUNDEVI
  • The Vice Rectory of Research of the University of Costa Rica

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