Total Synthesis of Reveromycin A
- 23 June 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (14) , 2153-2156
- https://doi.org/10.1021/ol0060634
Abstract
The stereoselective total synthesis of reveromycin A (1), a potent inhibitor of eukaryotic cell growth, has been accomplished on the basis of the stereocontrolled construction of the 6,6-spiroketal system, efficient succinylation of the tert-alcohol under high pressure, and the introduction of the unsaturated side chains.Keywords
This publication has 3 references indexed in Scilit:
- Enantioselective Synthesis of the [6,6] Spiroketal Core of Reveromycin AOrganic Letters, 1999
- Total Synthesis of Reveromycin BOrganic Letters, 1999
- Enantioselective Total Synthesis of Reveromycin BJournal of the American Chemical Society, 1998