G-quadruplex recognition by bis-indole carboxamides
- 5 June 2008
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 26,p. 3055-3057
- https://doi.org/10.1039/b806042h
Abstract
Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.Keywords
This publication has 45 references indexed in Scilit:
- Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognitionChemical Communications, 2008
- A hitchhiker's guide to G-quadruplex ligandsOrganic & Biomolecular Chemistry, 2007
- Trisubstituted Isoalloxazines as a New Class of G-Quadruplex Binding Ligands: Small Molecule Regulation of c-kit Oncogene ExpressionJournal of the American Chemical Society, 2007
- Macrocyclic and Helical Oligoamides as a New Class of G-Quadruplex LigandsJournal of the American Chemical Society, 2007
- Ligand‐Driven G‐Quadruplex Conformational Switching By Using an Unusual Mode of InteractionAngewandte Chemie International Edition in English, 2007
- An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translationNature Chemical Biology, 2007
- G-quadruplexes in promoters throughout the human genomeNucleic Acids Research, 2006
- Oxazole-Based Peptide Macrocycles: A New Class of G-Quadruplex Binding LigandsJournal of the American Chemical Society, 2006
- Tetramethylpyridiniumporphyrazines—a new class of G-quadruplex inducing and stabilising ligandsChemical Communications, 2006
- A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit OncogeneBiochemistry, 2006