Rab cascades and tethering factors in the endomembrane system
- 12 February 2007
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 581 (11) , 2125-2130
- https://doi.org/10.1016/j.febslet.2007.01.090
Abstract
Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues.Keywords
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