Expression of IAPs and Alternative Splice Variants in Hepatocellular Carcinoma Tissues and Cells
- 1 December 2004
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1028 (1) , 289-293
- https://doi.org/10.1196/annals.1322.033
Abstract
IAPs (inhibitors of apoptosis proteins) might have a major role in the apoptotic resistance that marks many cancers. The studies on IAPs in human HCC have focused on survivin or XIAP, indicating that their new or increased expression in this tumor is associated with a more unfavorable prognosis. The present results corroborate these findings, emphasizing the role that the coordinated expression of different IAPs and alternative splice variants might play in the adverse biology of hepatocellular carcinoma.Keywords
This publication has 5 references indexed in Scilit:
- The inhibitors of apoptosis: there is more to life than Bcl2Oncogene, 2003
- Survivin study: What is the next wave?Journal of Cellular Physiology, 2003
- Quantitative analysis of apoptosis‐related gene expression in hepatocellular carcinomaCancer, 2002
- NAIP-ΔEx10-11: a novel splice variant of the apoptosis inhibitor NAIP differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cellsLeukemia Research, 2002
- Survivin promotes cell proliferation in human hepatocellular carcinomaHepatology, 2000