INFLUENCE OF CELLULAR DNA CONTENT ON SURVIVAL IN ADVANCED OVARIAN-CANCER
- 1 January 1984
- journal article
- research article
- Vol. 44 (1) , 397-400
Abstract
Tumor cellular DNA content was measured by flow cytometry in 91 patients with advanced ovarian cancer, using a new and simple technique which allows archival paraffin-embedded tissue to be studied; 69% of the tumors were aneuploid, and 31% were diploid. Tumor ploidy was shown by multivariate Cox model analysis to be an independent prognostic variable and the major determinant of survival. Patients with diploid tumors survived significantly longer than did those with aneuploid tumors.This publication has 11 references indexed in Scilit:
- Flow cytometry in the diagnosis and classification of malignant lymphoma and leukemiaCancer, 1982
- Role of Anchorage in the Expression of Tumorigenicity of Untransformed Mouse Cell Lines23JNCI Journal of the National Cancer Institute, 1982
- DNA Distribution in Human Colon Carcinomas and Its Relationship to Clinical behavior2JNCI Journal of the National Cancer Institute, 1982
- The Significance of Ploidy and Proliferation in the Clinical and Biological Evaluation of Bladder Tumours: a Study of 100 Untreated CasesBritish Journal of Urology, 1982
- FLOW CYTOMETRIC ANALYSIS OF DNA CONTENT OF BONE-MARROW CELLS IN PATIENTS WITH PLASMA-CELL MYELOMA - CLINICAL IMPLICATIONS1982
- Cellular DNA content as a marker of neoplasia in manThe American Journal of Medicine, 1980
- CLONAL HETEROGENEITY OF SMALL-CELL ANAPLASTIC CARCINOMA OF THE LUNG DEMONSTRATED BY FLOW-CYTOMETRIC DNA ANALYSIS1980
- The pathological assessment of ovarian neoplasms. i: introduction to the common ‘epithelial’ tumours and analysis of benign ‘epithelial’ tumoursPathology, 1979
- DETERMINATION OF PLOIDY AND PROLIFERATIVE CHARACTERISTICS OF HUMAN SOLID TUMORS BY PULSE CYTOPHOTOMETRY1978
- CORRELATION OF DNA DISTRIBUTION ABNORMALITIES WITH CYTOGENETIC FINDINGS IN HUMAN ADULT LEUKEMIA AND LYMPHOMA1977