Comparison of data compiled during the past 60 years with those from recent studies shows that major changes have occurred in the bottom and fish faunas of Lake Erie. The bottom fauna was formerly dominated by the nymphs of Hexagenia, but at present midge larvae and oligochaetes are most abundant. Blue pike (Stizostedion vitreum glaucum) and cisco (Coregonus artedii), which formerly dominated the commercial catch, are scarce, while other species are more plentiful than formerly. The concentrations of various major ions have increased as much as 10 p.p.m. The mean annual water temperatures are approximately 2° F. warmer today than during the 1918‐28 period. Low levels of dissolved oxygen have been observed several times since 1930, and recently very low concentrations were found in the bottom waters covering many square miles of the central basin. Although similar conditions may have existed in the past, it appears that greater areas are involved at the present.