Trasylol Prevents Trypsin-Induced Shock in Dogs

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Abstract
The effect of simultaneous i.v. administration in the dog of bovine trypsin and Trasylol followed by continued infusion of Trasylol was studied. The interchange between the dominating plasma protease inhibitors .alpha.1-antitrypsin and .alpha.-macroglobulins and the disappearance of Trasylol and its trypsin complexes from the circulation were studied. Trypsin was preferentially bound by the .alpha.-macroglobulins though Trasylol is a strong trypsin inhibitor. On saturation of the .alpha.-macroglobulins a considerable amount of trypsin was bound by .alpha.1-antitrypsin. Trasylol was bound to the trypsin-.alpha.-macroglobulin complexes and then rapidly eliminated from the circulation. On saturation of the .alpha.-macroglobulins Trasylol was identified in a free form; increasing amounts of Trasylol were also bound to trypsin. This may be explained by direct complexation of Trasylol and trypsin and by a transfer of trypsin from unstable trypsin-.alpha.1-antitrypsin complexes to free Trasylol.