Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
Top Cited Papers
- 23 March 2007
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 315 (5819) , 1687-1691
- https://doi.org/10.1126/science.1139393
Abstract
A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity.Keywords
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