Role of curdlan sulfate in the production of , -chemokines and interleukin-16
- 10 August 1998
- journal article
- Published by Springer Nature in Medical Microbiology and Immunology
- Vol. 187 (1) , 43-48
- https://doi.org/10.1007/s004300050072
Abstract
The blocking effect of curdlan sulfate (CRDS) on human immunodeficiency virus (HIV) infection has been thought to be related to inhibition of the binding of HIV-1 envelope glycoprotein (gp120) and CD4 molecules. However, recent reports have indicated that blocking the binding of gp120 to CD4 by CRDS only makes a small contribution to the inhibition of HIV-1 infection. We report here that the effect of CRDS on the production of β-chemokines and cytokines might be important in the inhibition of HIV-1 infection, in addition to interference with the binding of gp120 to CD4+ cells.Keywords
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