Synthesis and Antiviral Activity of Carbocyclic 5-Substituted Uridines and Cytidines

Abstract
Some carbocyclic uridines and cytidines have been prepared in a palladium-catalyzed reaction between 5-substituted uracils and cytosines and diacetoxymethylcyclopentene, prepared in a Prins reaction. The antiviral activity of the nucleoside analogues have been tested.