Dystrophin as a focal adhesion protein

Publisher Website
Google Scholar
Abstract
Monoclonal antibodies against dystrophin and the postsynaptic 58 kDa protein from Torpedo electric organ were used to localize homologs of these proteins in cultured skeletal muscle (Xenopus laevis). The Xenopus homolog is an M r 48000 protein and, like dystrophin, is a sarcolemmal protein. Both proteins localized precisely to talin‐positive sites, hence with each other, on the substrate‐apposed sarcolemma. Therefore, the first sites of appearance of dystrophin on cultured muscle cells are focal adhesions, i.e. specific sites of cytoskeleton/extracellular matrix interaction. These data also add to evidence that dystrophin and the 58 kDa act together.