Possible Role of Androgen Receptors in Amyotrophic Lateral Sclerosis
- 1 March 1980
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 37 (3) , 129-131
- https://doi.org/10.1001/archneur.1980.00500520027002
Abstract
• Androgen receptors have been demonstrated in both cranial nerve and spinal motor neurons. This article proposes that amyotrophic lateral sclerosis (ALS) may be a disease in which androgen receptors in motor neurons are lost or not functioning. This is suggested by the male-to-4 female ratio of the disease, the age of onset, and the sparing of neurons of cranial nerves III, IV, and VI that coincidentally lack androgen receptors. The hypothesis is that ALS may be due to a loss of androgen receptors that results in an inability to respond to a variety of Insults Including axonal damage.Keywords
This publication has 12 references indexed in Scilit:
- Distribution of Androgen-Concentrating Neurons in Rat Brain1Published by S. Karger AG ,2015
- Sparing of the onufrowicz nucleus in sacral anterior horn lesionsAnnals of Neurology, 1978
- Retrograde responses of developing lateral motor column neuronsJournal of Comparative Neurology, 1978
- Androgen Concentration in Motor Neurons of Cranial Nerves and Spinal CordScience, 1977
- Androgen and estrogen binding in rat skeletal and perineal musclesCanadian Journal of Biochemistry, 1976
- Estrogen-Topographical Localization of Estrogen-Concentrating Cells in the Rat Spinal Cord Following 3H-Estradiol AdministrationExperimental Biology and Medicine, 1973
- Proximal axonal enlargement in motor neuron diseaseNeurology, 1968
- Course and Prognosis in Amyotrophic Lateral SclerosisArchives of Neurology, 1963
- A Study of the Loss of Nerve Cells in the Central Nervous System in Relation to AgeGerontology, 1959
- A CASE OF AMYOTROPHIC LATERAL SCLEROSIS WITH DEGENERATION OF THE MOTOR PATH FROM THE CORTEX TO THE PERIPHERYBrain, 1895